APPLICATIONS OF GRAPH THEORY FOR REUSE OF MODEL BASED SYSTEMS ENGINEERING DESIGN DATA

This dissertation contributes to systems engineering (SE) by introducing and demonstrating a novel graph-based design repository (GBDR) tool. GBDR enables engineers to leverage system design information from a heterogenous set of system models created using multiple model based systems engineering (MBSE) software tools as an integrated body of knowledge. Specifically, the research provides a set of approaches that allow the use of system models described in Systems Modeling Language and Lifecycle Modeling Language as an integrated body of design information. The coalesced body of system design information serves to support concept ideation and analysis within SE. The research accomplishes this by using a graph database to store system model information imported from digital artifacts created by MBSE tools and applying principles from graph theory and semantic web technologies to identify likely connections and equivalent concepts across system models, modeling languages, and metamodels. The research demonstrates that the presented tool can import, store, synthesize, search, display, distribute, and export information from multiple MBSE tools. As a practical demonstration, feasible subsystem design alternatives for a small unmanned aircraft system government reference architecture are identified from within a set of existing system models.OSD CAPECivilian, Office of the Secretary of DefenseApproved for public release. Distribution is unlimited

Modeling Supermassive Primordial Stars with MESA

Supermassive stars forming at $z \sim$ 15 - 20 are one of the leading contenders for the origin of the first quasars, over 200 of which have now been discovered at $z >$ 6. These stars likely form in pristine, atomically cooled haloes immersed in strong Lyman-Werner UV backgrounds or in highly supersonic baryon streaming flows. Atomic cooling triggers catastrophic baryon collapse capable of building up stars at rates of up to $\sim$1 M$_{\odot}$ yr$^{-1}$. Here we examine the evolution of supermassive stars with a much larger and finer grid of accretion rates than in previous studies with the \texttt{MESA} stellar evolution code. We find that their final masses range from 3.5 $\times$ 10$^3$ M$_{\odot}$ - 3.7 $\times$ 10$^5$ M$_{\odot}$ at accretion rates of 0.001 M$_{\odot}$ yr$^{-1}$ - 1 M$_{\odot}$ yr$^{-1}$, respectively. We also find that supermassive star evolution diverges at accretion rates of 0.01 M$_{\odot}$ yr$^{-1}$ - 0.02 M$_{\odot}$ yr$^{-1}$, above which they evolve as cool red hypergiants along the Hayashi track and collapse via the general relativistic instability during central hydrogen burning, and below which they evolve as hot blue supergiants and collapse at the end of their nuclear burning lifetimes after exiting the main sequence.Comment: 11 pages, 10 figures, accepted by MNRA

Changing the rules at the drop of a hat: An ERP study of preschoolers\u27 set-shifting ability

We examined the neural correlates of set-shifting in 5-year-old children and examined whether the ease of switching was affected by varying the number of non-switch trials preceding a switch

Changing the rules at the drop of a hat: An ERP study of preschoolers\u27 set-shifting ability

We examined the neural correlates of set-shifting in 5-year-old children and examined whether the ease of switching was affected by varying the number of non-switch trials preceding a switch

Turbulent Cold Flows Gave Birth to the First Quasars

How quasars powered by supermassive black holes (SMBHs) formed less than a billion years after the Big Bang is still one of the outstanding problems in astrophysics 20 years after their discovery$^{1-4}$. Cosmological simulations suggest that rare cold flows converging on primordial haloes in low-shear environments could have created these quasars if they were 10$^4$ - 10$^5$ M$_{\odot}$ at birth but could not resolve their formation$^{5-8}$. Semianalytical studies of the progenitor halo of a primordial quasar found that it favours the formation of such seeds but could not verify if one actually appeared$^9$. Here we show that a halo at the rare convergence of strong, cold accretion flows creates massive BH seeds without the need for UV backgrounds, supersonic streaming motions, or even atomic cooling. Cold flows drive violent, supersonic turbulence in the halo that prevents star formation until it reaches a mass that triggers sudden, catastrophic baryon collapse that forms 31,000 and 40,000 M$_{\odot}$ stars. This simple, robust process ensures that haloes capable of forming quasars by z $>$ 6 produce massive seeds. The first quasars were thus a natural consequence of structure formation in cold dark matter cosmologies, not exotic, finely-tuned environments as previously thought$^{10-14}$.Comment: Author's version of a Letter published in Nature on July 6th, 202

What turns galaxies off? The different morphologies of star-forming and quiescent galaxies since z~2 from CANDELS

We use HST/WFC3 imaging from the CANDELS Multicycle Treasury Survey, in conjunction with the Sloan Digital Sky Survey, to explore the evolution of galactic structure for galaxies with stellar masses >3e10M_sun from z=2.2 to the present epoch, a time span of 10Gyr. We explore the relationship between rest-frame optical color, stellar mass, star formation activity and galaxy structure. We confirm the dramatic increase from z=2.2 to the present day in the number density of non-star-forming galaxies above 3e10M_sun reported by others. We further find that the vast majority of these quiescent systems have concentrated light profiles, as parametrized by the Sersic index, and the population of concentrated galaxies grows similarly rapidly. We examine the joint distribution of star formation activity, Sersic index, stellar mass, inferred velocity dispersion, and stellar surface density. Quiescence correlates poorly with stellar mass at all z<2.2. Quiescence correlates well with Sersic index at all redshifts. Quiescence correlates well with `velocity dispersion' and stellar surface density at z>1.3, and somewhat less well at lower redshifts. Yet, there is significant scatter between quiescence and galaxy structure: while the vast majority of quiescent galaxies have prominent bulges, many of them have significant disks, and a number of bulge-dominated galaxies have significant star formation. Noting the rarity of quiescent galaxies without prominent bulges, we argue that a prominent bulge (and perhaps, by association, a supermassive black hole) is an important condition for quenching star formation on galactic scales over the last 10Gyr, in qualitative agreement with the AGN feedback paradigm.Comment: The Astrophysical Journal, in press; 20 pages with 13 figure

Development and Validation of Risk Prediction Models for Cardiovascular Events in Black Adults: The Jackson Heart Study Cohort

Cardiovascular risk assessment is a fundamental component of prevention of cardiovascular disease (CVD). However, commonly used prediction models have been formulated in primarily or exclusively white populations. Whether risk assessment in black adults is dissimilar to that in white adults is uncertain

Reliability of the tuck jump injury risk screening assessment in elite male youth soccer players

Altered neuromuscular control has been suggested as a mechanism for injury in soccer players. Ligamentous injuries most often occur during dynamic movements, such as decelerations from jump-landing maneuvers where high risk movement patterns are present. The assessment of kinematic variables during jump-landing tasks as part of a pre-participation screen is useful in the identification of injury risk. An example of a field-based screening tool is the repeated tuck jump assessment. The purpose of this study was to analyze the within-subject variation of the tuck jump screening assessment in elite male youth soccer players. 25 pre and 25 post-peak height velocity (PHV) elite male youth soccer players from the academy of a professional English soccer club completed the assessment. A test, re-test design was used to explore the within-subject inter-session reliability. Technique was graded retrospectively against the 10-point criteria set out in the screening protocol using two-dimensional video cameras. The typical error range reported for tuck jump total score (0.90 – 1.01 in pre and post-PHV players respectively) was considered acceptable. When each criteria was analyzed individually, Kappa coefficient determined that knee valgus was the only criterion to reach substantial agreement across the two test sessions for both groups. The results of this study suggest that although tuck jump total score may be reliably assessed in elite male youth soccer players, caution should be applied in solely interpreting the composite score due to the high within-subject variation in a number of the individual criteria. Knee valgus may be reliably used to screen elite youth male soccer players for this plyometric technique error and for test, re-test comparison

Adherence to guidelines strongly improves reproducibility of brachial artery flow-mediated dilation.

BACKGROUND: Brachial artery FMD is widely used as a non-invasive measure of endothelial function. Adherence to expert guidelines is believed to be of vital importance to obtain reproducible measurements. We conducted a systematic review of studies reporting on the reproducibility of the FMD in order to determine the relation between adherence to current expert guidelines for FMD measurement and its reproducibility. METHODS: Medline-database was searched through July 2015 and 458 records were screened for FMD reproducibility studies reporting the mean difference and variance of repeated FMD measurements. An adherence score was assigned to each of the included studies based on reported adherence to published guidelines on the assessment of brachial artery FMD. A Typical Error Estimate (TEE) of the FMD was calculated for each included study. The relation between the FMD TEE and the adherence score was investigated by means of Pearson correlation coefficients and multiple linear regression analysis. RESULTS: Twenty-seven studies involving 48 study groups and 1537 subjects were included in the analyses. The adherence score ranged from 2.4 to 9.2 (out of a maximum of 10) and was strongly and inversely correlated with FMD TEE (adjusted R(2) = 0.36, P < 0.01). Use of automated edge-detection software, continuous diameter measurement, true peak diameter for %FMD calculation, a stereostatic probe holder, and higher age emerged as factors associated with a lower FMD TEE. CONCLUSIONS: These data demonstrate that adherence to current expert consensus guidelines and applying contemporary techniques for measuring brachial artery FMD decreases its measurement error

The sensitivity of ECG contamination to surgical implantation site in brain computer interfaces.

BACKGROUND Brain sensing devices are approved today for Parkinson's, essential tremor, and epilepsy therapies. Clinical decisions for implants are often influenced by the premise that patients will benefit from using sensing technology. However, artifacts, such as ECG contamination, can render such treatments unreliable. Therefore, clinicians need to understand how surgical decisions may affect artifact probability. OBJECTIVES Investigate neural signal contamination with ECG activity in sensing enabled neurostimulation systems, and in particular clinical choices such as implant location that impact signal fidelity. METHODS Electric field modeling and empirical signals from 85 patients were used to investigate the relationship between implant location and ECG contamination. RESULTS The impact on neural recordings depends on the difference between ECG signal and noise floor of the electrophysiological recording. Empirically, we demonstrate that severe ECG contamination was more than 3.2x higher in left-sided subclavicular implants (48.3%), when compared to right-sided implants (15.3%). Cranial implants did not show ECG contamination. CONCLUSIONS Given the relative frequency of corrupted neural signals, we conclude that implant location will impact the ability of brain sensing devices to be used for "closed-loop" algorithms. Clinical adjustments such as implant location can significantly affect signal integrity and need consideration